About this trial
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected. Maintaining blood pressure becomes is an important part of treatment as it supports recovery of the injured spinal cord. Blood pressure is most often increased using vasopressors, such as norepinephrine. Although these drugs help maintain blood flow, they may also lead to increased bleeding in the injury site, making the lesion worse. Alternatively, dobutamine, a medication that helps the heart pump more effectively, has shown to maintain blood pressure and improve prefusion at the injury site. This study will assess dobutamine capacity to maintain blood pressure acutely post injury.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Complete (AIS A) or incomplete (AIS B) acute traumatic SCI involving bony spinal levels between C0 and T1 (inclusive)
Able to communicate in English and provide informed consent
Disqualifiers
History and/or symptoms of cardiovascular disease (Type 2 Diabetes is ok) or cardiopulmonary problems/disease, including uncontrolled hypertension
Traumatic brain injury that is severe enough to preclude neurologic assessment of SCI impairment and assignment of AIS grade A or B.
Aneurysms of the thoracic aorta
Pregnant
Trial design
Single group
Treatments tested in this trial
Dobutamine crossover
DrugCross-over from norepinephrine to dobutamine
Treatment groups
Trial outcomes
Primary outcomes
Mean arterial blood pressure
Secondary outcomes
Cardiac stroke volume index
Sponsors and contacts
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University of British Columbia
Lead sponsor
United States Department of Defense
Collaborator
This trial is not recruiting at the moment. You can still explore other options: