Cocaine and Pentoxifylline (BED IN 47)
ConditionCocaine Use Disorder
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-55
SponsorWilliam Stoops
About this trial
This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
able to speak/read English,
not seeking treatment for drug use at the time of the study,
female or male between the ages of 18 and 55 years,
recent smoked or intravenous cocaine use verified by benzoylecgonine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for CUD,
Disqualifiers
unable to speak/read English,
seeking treatment for drug use,
under 18 years or over 55 years,
no recent smoked or intravenous cocaine use as indicated by benzoylecgonine negative urine and no DSM-5 diagnosis of CUD,
Trial design
Design model
Crossover
Treatments tested in this trial
Placebo
DrugThe effects of placebo will be determined.
Cocaine (IV)
DrugThe effects of IV Cocaine will be determined.
Pentoxifylline
DrugThe effects of pentoxifylline will be determined.
Treatment groups
30 Participants
are divided into 3 treatment groupsGroup A: PlaceboPlacebo comparator 1 intervention
Group B: Pentoxifylline Dose 1Experimental treatment 3 interventions
Group C: Pentoxifylline Dose 2Experimental treatment 3 interventions
Trial outcomes
Primary outcomes
1
Reinforcing Effects of Cocaine
Number of Times Subjects Choose Cocaine (Maximum of 5 Choices) Over Money
Time frame
9 times over approximately 1 month inpatient admissionSponsors and contacts
Click on the lead sponsor to view all of their trials.
William Stoops
Lead sponsor
University of Kentucky
Sponsor institution
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov