Cognition and Motor Learning Post-stroke
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age45-85
SponsorUniversity of Southern California
About this trial
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Unilateral stroke
Stroke occurred more than 6 months prior
Paresis confined to one side
Independently ambulatory (including the use of assistive devices)
Disqualifiers
Brainstem or cerebellar stroke
Aphasia (expressive, receptive, or global)
Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
Trial design
Design model
Single group
Treatments tested in this trial
Explicit motor learning
BehavioralParticipants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
Implicit motor learning
BehavioralParticipants will walk on a treadmill that drives their right and left legs to move at two different speeds.
Treatment groups
65 Participants
are divided into 1 treatment groupGroup A: Evaluating motor learning and brain structures post-strokeExperimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
step length asymmetry - change in performance
characterized as a comparison between the right and left step lengths; captured to quantify change in performance with biofeedback or split belt walking
Time frame
Measured at three timepoints of interest within each testing session: baseline and at the beginning and end of the interventions; participants will complete 2 testing sessions over approximately 1 monthsSecondary outcomes
1
step length asymmetry - immediate retention
characterized as a comparison between the right and left step lengths; captured to quantify the retention of a newly learned walking pattern
Time frame
Measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 monthsSponsors and contacts
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Source ClinicalTrials.gov