About this trial
This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Willing and able to provide informed consent
Aged 18-65 years
Self-reported low levels of positive mood
Sufficient written and spoken English skills to understand study procedures
Disqualifiers
Antidepressant treatment or medication in last three months
Currently receiving cognitive-behavioural therapy with behavioural activation
History of psychosis or bipolar disorder
History of substance dependence
Trial design
Parallel
Treatments tested in this trial
Losartan with BA
Drug7-day losartan (Cozaar, 50mg; oral tablet) with 7-day BA
Placebo with BA
Other intervention7-day placebo (oral; microcellulose in identical capsules) with 7-day BA
Treatment groups
Trial outcomes
Primary outcomes
Change in reinforcement learning
reinforcement learning, calculated as the learning rate from negative and positive decision outcomes. Larger scores indicate better learning from an outcome.
Secondary outcomes
Change in approach-avoidance-task (AAT) effect score
mean reaction time of the pull trials of a valence category subtracted from the push trials of the same category, yielding a single indicator of approach/avoidance, with positive scores indicating relatively stronger approach and negative scores indicating relatively stronger avoidance
Change in social approach decisions
% approach vs avoid decisions
Change in motivational effort in the Apples Task
The task weighs effort costs against reward value. It involves a hand dynamometer to record effort. On each trial, participants receive an offer showing a reward (number of apples shown on a tree) and an effort level (height of marking on the tree trunk), which they can accept or reject (Yes/No response). On a subset of accepted trials, participants have to exert physical effort on the hand dynamometer to earn the reward (number of apples in the respective trial). Participants receive monetary reward for the number of apples collected. Key outcome marker is effort-reward valuation, i.e. % accepted trials based on combinations of effort and reward levels. Other outcomes: Force exerted relative to Maximum Voluntary Contraction (MVC), Reaction times of Yes/No.
Sponsors and contacts
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