Early Neurovascular Adaptations in Aging Women
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18-70
SponsorUniversity of Missouri-Columbia
About this trial
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Assigned female at birth (AFAB)
18-70 years of age
Disqualifiers
Assigned male at birth (AMAB)
Pregnancy, breastfeeding
Body mass index ≥30 kg/m2
Taking medications known to affect metabolic, autonomic, and/or respiratory function
Trial design
Design model
Single group
Treatments tested in this trial
Norepinephrine
DrugInfused intra-arterially in a dose-response fashion
Isoproterenol
DrugInfused intra-arterially in a dose-response fashion
Acetylcholine
DrugInfused intra-arterially in a dose-response fashion
Nitroprusside
DrugInfused intra-arterially in a dose-response fashion
Estrogen
DrugInfused intra-arterially
Treatment groups
64 Participants
are divided into 1 treatment groupGroup A: WomenOther 5 interventions
Trial outcomes
Primary outcomes
1
Magnitude of forearm blood flow
Time frame
Change from baseline during infusionSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Missouri-Columbia
Lead sponsor
American Heart Association
Collaborator
Source ClinicalTrials.gov