Efficacy of Topical Tyrosine Versus Topical 5-Fluorouracil With Fractional Erbium YAG Laser

ConditionFocal Vitiligo

Trial statusRecruiting

Trial phaseEarly Phase 1

Trial typeInterventional

Biological sexAll

Age18-60

SponsorAswan University

About this trial

Vitiligo is an autoimmune disorder affecting the skin, specifically targeting pigment-producing melanocytes, leading to noticeable regions of depigmentation characterized by white spots.

It is a widely prevalent skin disorder globally, affecting males and females almost equally, although it is reported slightly more frequently in females. In more than 60% of patients, the disease begins before the age of 30 and It has an estimated prevalence of roughly 0.2-2% across various populations, with around 0.4% in the European-derived white (EUR) population.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Pregnancy.

Lactation.

Patients with segmental vitiligo.

Patients with autoimmune disease including thyroiditis.

Trial design

Design model

Parallel

Treatments tested in this trial

Tyrosine
Drug
to evaluate and compare the therapeutic effects of topical tyrosine and topical( 5-FU) combined with fractional erbium:YAG laser in the treatment of focal vitiligo.

Treatment groups

40 Participants

are divided into 2 treatment groups

Group A: Topical 5-Fluorouracil GroupActive comparator 1 intervention

Group B: L-tyrosine Cream GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

Treatment of Focal Vitiligo

To measure the efficacy of the treatment by Topical Tyrosine and Topical 5-Fluorouracil With Fractional Erbium YAG Laser in repigmentation, assessed by the change in the Vitiligo Area Scoring Index (VASI ) which is determined by summing the products of the number of hand units and the percentage of depigmentation for each lesion, using predefined categories of 0%, 10%, 25%, 50%, 75%, 90%, and 100%. where as 0% is the worst and 100% is the best.

Time frame

1 year

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Aswan University

Lead sponsor

Source ClinicalTrials.gov

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