Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-45
SponsorRajesh Narendran
About this trial
Studies proposed in this application will image mitochondrial Complex-I in cocaine use disorder (CUD) and matched healthy controls
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Males or females between 18 and 45 years old.
fulfill DSM-5 criteria for moderate or severe (4+ criteria) cocaine use disorder.
No lifetime DSM-5 schizophrenia, schizoaffective disorder, bipolar disorder, and developmental disorders.
No comorbid DSM-5 major depressive or severe anxiety disorders (including cocaine-induced mood and anxiety disorders) in the past 12 months.
Disqualifiers
None
Trial design
Design model
Single group
Treatments tested in this trial
[F-18]BCPP-EF
DrugRadiotracer
Treatment groups
40 Participants
are divided into 1 treatment groupGroup A: PETExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Orbitofrontal Cortex [F-18]BCPP-EF VT
VT is the volume of distribution expressed relative to total plasma radioligand concentration
Time frame
Baseline scan (time 0)2
Midbrain [F-18]BCPP-EF VT
VT is the volume of distribution expressed relative to total plasma radioligand concentration
Time frame
Baseline scan (time 0)3
Ventral Striatum [F-18]BCPP-EF VT
VT is the volume of distribution expressed relative to total plasma radioligand concentration
Time frame
Baseline scan (time 0)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Rajesh Narendran
Lead sponsor
University of Pittsburgh
Sponsor institution
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov