Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18-70
SponsorUniversity of Missouri-Columbia
About this trial
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Female assigned at birth
Pre, peri- or post-menopausal
Healthy weight (BMI ≥18 and ≤30 kg/m2)
Disqualifiers
Male (assigned at birth)
Pregnancy, breastfeeding
Use of hormone replacement therapies
Hysterectomy
Trial design
Design model
Crossover
Treatments tested in this trial
Placebo
DrugParticipants will receive a placebo in pill form.
Propranolol
DrugParticipants will receive oral propranolol (1 mg/kg).
Gemtesa
DrugParticipants will receive oral gemtesa (75 mg).
Treatment groups
75 Participants
are divided into 3 treatment groupsGroup A: HypoxiaExperimental treatment 3 interventions
Group B: Cold pressor testExperimental treatment 3 interventions
Group C: HypercapniaExperimental treatment 3 interventions
Trial outcomes
Primary outcomes
1
Forearm blood flow
Blood flow in the forearm measured with venous occlusion plethysmography.
Time frame
Change from baseline to 5 minutes.Sponsors and contacts
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Source ClinicalTrials.gov