Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis

ConditionsTreatment of Stage III Periodontitis Local Application of Insulin in Pockets

Trial statusRecruiting

Trial phaseEarly Phase 1

Trial typeInterventional

Biological sexAll

AgeNot listed

SponsorDoaa Atta Aid

About this trial

The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus hyaluronic acid as an adjunct to non surgical periodontal therapy in stage Ⅲ periodontitis patients.

This will be done by:

1. Clinical assessment. 2. Biochemical analysis. - Dose the topical application of insulin or hyaluronic acid as an adjunct to non-surgical periodontal therapy improves periodontal condition in stage Ⅲ periodontitis patients? PICO P (Population): patients with stage Ⅲ periodontitis. I (Intervention): non surgical periodontal therapy (SRP) with topical application using insulin or hyaluronic acid in periodontal pockets.

C (Comparison): topical application of insulin versus hyaluronic acid and SRP alone in periodontal pocket.

O (Outcome): primary outcome: change in periodontal pocket depth (PPD) or clinical attachment loss (CAL). Secondary outcome: change in gingival index (GI) or bleeding on probing index (BOP) and levels of IL-1β in GCF of treated pocket.

Study type: Randomized controlled trials (RCTs).

Eligibility criteria

Qualifiers

All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index.

Should be diagnosed as having periodontitis.

Not received any type of periodontal treatment in the past 6 months prior to examination.

Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits.

Disqualifiers

Antibiotic therapy in the preceding 6 months or during study participation.

History of insulin dependent diabetes and thyroid disease.

Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug.

Poor oral hygiene compliance or inability to adhere to the clinical protocol.

Trial design

Treatments tested in this trial

Insulin
Hyaluronic acid gel
mechanical debridement

Treatment groups

45 Participants

are divided into 3 treatment groups

Sponsors and collaborators

Doaa Atta Aid

Lead sponsor

Faculty of Dental Medicine for Girls

Sponsor institution

Al-Azhar University

Collaborator

Source ClinicalTrials.gov