Health TrialsbyHealthPanel

Multi-organ Imaging of Microvascular and Metabolic Function

ConditionsHealthy Subjects (HS)Cardiovascular Diseases (CVD)
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorMassachusetts General Hospital

About this trial

What if heart disease starts outside the heart? This research will study how to simultaneously assess brain and body physiology, how they are jointly related to heart function, and how their response to physical and mental stress differs in patients with heart disease.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults aged 18 years and older

For patients with cardiovascular disease: Documented diagnosis of ischemic heart disease based on standard clinical, radiologic, and/or histopathologic criteria, as documented in the medical record; or a clinical nuclear cardiac stress PET test within 1 year.

For healthy subjects: No diagnosis of cardiometabolic disease, cancer, or other major disease within the past 5 years

Disqualifiers

Research-related radiation exposure exceeding current MGB Radiology Department guidelines (i.e., 50 mSv in the prior 12 months);

Inability to lie comfortably on the bed inside the scanner;

Body weight > 300 lbs (weight limit of the scanner table);

Pregnancy or breastfeeding;

Trial design

Design model

Single group

Treatments tested in this trial

  • 18F-FDG

    Drug

    Dynamic 18F-FDG PET

  • Positron Emission Tomography (PET)

    Device

    Panorama GS PET/CT

Treatment groups

60 Participants
are divided into 1 treatment group
Group A: Dynamic PET/CT scanExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Blood flow responses

The primary endpoint is to evaluate if blood flow responses to acute stressors can be quantitatively measured with 18F-FDG

Time frame
During the procedure

Secondary outcomes

1

Glucose metabolism responses

The secondary endpoint is to evaluate if glucose metabolic responses to acute stressors can be quantitatively measured with 18F-FDG

Time frame
During the scan

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Massachusetts General Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: