Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age50-80
SponsorTeachers College, Columbia University

About this trial

The goal of this clinical trial is to learn whether noise-augmented feedback using automatic speech recognition improves intelligibility and social participation in individuals with Parkinson's disease. The main questions the investigators will address are:

Does noise-augmented feedback lead to increased intelligibility, as measured by transcription accuracy scores?

Does a self-managed speech protocol lead to increased social participation, as measured by the Communicative Participation Item Bank and the Communicative Effectiveness Index questionnaires?

Participants will:

Receive 2-4 initial speech assessments in-person in our lab. Engage in speech treatment sessions at home using their phone and computer four days a week for four weeks. Four of those sessions will be directly monitored online by a speech-language pathologist. The rest of the sessions are completed by the participant.

Come to the lab for two post-treatment assessments following completion of treatment.

Come to the lab six months after treatment completion for an additional assessment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

They are 50-80 years old,

They have a medical diagnosis of PD,

They are within stages I-IV of Hoehn & Yahr Scale,

Their antiparkinsonian medication schedule is stable,

Disqualifiers

Present with atypical parkinsonism at the time of screening (or other neurological condition),

Underwent neurosurgery treatment (DBS),

Received intensive voice-focused treatment less than three months prior to their involvement in the current study,

Present with any speech or voice pathology that is unrelated to PD.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Immediate treatment

    Behavioral

    Participants will access a web-based app using their phone to record 100 sentences every treatment session. Noise-augmented feedback will be provided to increase accuracy of speech productions.

  • Deferred treatment

    Behavioral

    This group of participants will receive the same treatment as those in the immediate treatment group. The only difference is the timeline of treatment onset. Therefore, participants will access a web-based app using their phone to record 100 sentences every treatment session. Noise-augmented feedback will be provided to increase accuracy of speech productions.

Treatment groups

42 Participants
are divided into 2 treatment groups
Group A: Immediate treatmentExperimental treatment 1 intervention
Group B: Deferred treatmentActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Intelligibility

Transcription accuracy (% words correctly understood by listeners)

Time frame
3 years

Secondary outcomes

1

Social participation

Communicative Participation Item Bank questionnaire (10 questions, 0 = very much to 3 = not at all)

Time frame
7-8 months
2

Social participation

Communication Effectiveness Index questionnaire (8 questions, 1 = not at all effective, 4 = very effective)

Time frame
7-8 months

Other outcomes

Sponsors and contacts

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