Health TrialsbyHealthPanel

Propranolol in Primary Progressive Aphasia

ConditionAphasia, Primary Progressive
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age50+
SponsorUniversity of Missouri-Columbia

About this trial

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure.

This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1. Age: 50 and older

2. Primary Progressive Aphasia diagnosis

3. Native English speaker

Disqualifiers

1. Unable to provide consent

2. Taking alpha 2 agonists (clonidine and guanfacine)

3. Other major psychological or neurological diagnosis

4. Major head trauma that contributed to their condition

Trial design

Design model

Crossover

Treatments tested in this trial

  • Propranolol

    Drug

    Propranolol will be given on a titration schedule in which participants will begin with small doses of the drug and increase to a larger dosage over the course of three weeks. Propranolol will be taken for a total of 9 weeks.

  • Magnetic Resonance Imaging (MRI)

    Device

    Magnetic Resonance Imaging (MRI) will be performed at 3 Tesla and 7 Tesla, for both propranolol and placebo arms.

  • Placebo

    Drug

    Placebo will be given on the same schedule as the propranolol regime.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Propanolol and MRIExperimental treatment 2 interventions
Group B: Placebo and MRIPlacebo comparator 2 interventions

Trial outcomes

Primary outcomes

1

Change in Neuropsychological Assessment Battery Naming Test

Time frame
Day 1, 4 Weeks, 8 Weeks, 10 Weeks, 14 Weeks,18 Weeks

Secondary outcomes

1

Change in State-Trait Anxiety Inventory for Adults

The State-Trait Anxiety scores range from 20-40. A higher score indicates more anxiety.

Time frame
Day 1, 4 Weeks, 8 Weeks, 10 Weeks,14 Weeks,18 Weeks
2

Change in Semantic Word Fluency Tasks

The Semantic Word Fluency task measures the subject's ability to name as many items in a minute in a given category. The total number of correct and non-repeated responses are totaled for each category. There is no minimum or maximum score. Higher scores indicate better word fluency.

Time frame
Day 1, 8 Weeks,18 Weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Missouri-Columbia

Lead sponsor

Source ClinicalTrials.gov
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