S1R Imaging-Based Cryoneurolysis in Chronic Pain
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorDavidzon, Guido, M.D.
About this trial
The goal of this clinical trial is to determine whether a sigma-1 receptor PET/MRI scan can help identify the specific nerves responsible for chronic pain.
Researchers will use an investigational imaging agent called \[18F\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests.
Participants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.
Eligibility criteria
Qualifiers
Chronic nociceptive, neuropathic, or mixed pain for ≥2 months
Pain originating from a region amenable to cryoneurolysis (celiac plexus, intercostal nerves, pudendal nerve, peripheral nerve block
Chronic pain ≥2 months
Pain score ≥4/10
Disqualifiers
Pregnancy or nursing.
Non-English speaking individuals
Contraindication to MRI scanning which includes, but is not limited to, incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ.
Weight >350 pounds or a large body habitus, which the MR scanner cannot accommodate.
Trial design
Treatments tested in this trial
- [18F]-FTC-146
Treatment groups
6 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Davidzon, Guido, M.D.
Lead sponsor
Stanford University
Sponsor institution
Society of Interventional Radiology Foundation
Collaborator
Source ClinicalTrials.gov