Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
ConditionAcute Kidney Injury
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorXijing Hospital
About this trial
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.
Eligibility criteria
Qualifiers
None
Disqualifiers
congenital heart disease,
surgery requiring deep hypothermic circulatory arrest,
a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²,
AKI already present prior to ICU admission
Trial design
Treatments tested in this trial
- L-arginine
Treatment groups
5,000 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov