Eccentric Exercise Rehabilitation After Myocardial Infarction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age50-75
SponsorMedical University of Gdansk
About this trial
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise.
The main aim of the study is to determine whether eccentric exercise affects blood levels of proteins released or regulated in response to physical activity, including musclin, interleukin-6, and myostatin. The study will also evaluate whether the program improves physical performance and functional capacity.
Participants will complete eccentric cycling exercise on a semi-recumbent cycle ergometer during a two-week cardiac rehabilitation program. Blood samples and physical-function measurements will be collected before and after the intervention.
Eligibility criteria
Qualifiers
Documented history of myocardial infarction confirmed by medical records.
Qualification for stage I comprehensive inpatient cardiac rehabilitation.
Clinically stable condition allowing participation in exercise-based cardiac rehabilitation.
New York Heart Association functional class I or II.
Disqualifiers
Any contraindication to exercise-based cardiac rehabilitation or exercise testing.
Acute myocardial infarction within the first 4 days before planned initiation of exercise rehabilitation.
Unstable angina.
Significant left main coronary artery stenosis considered a contraindication to exercise by the treating cardiologist.
Trial design
Treatments tested in this trial
- Standard Inpatient Cardiac Rehabilitation
- Eccentric Cycling Exercise
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov