Eccentric Muscle Training in Cardiac Rehabilitation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorUniversity Hospital, Antwerp

About this trial

The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.

Researchers will compare a training program of eccentric overload training and eccentric cycling training with a traditional training program of strength and cardio training in people with heart failure with reduced ejection fraction.

This study will be delivered in a cardiac rehabilitation setting.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

HFrEF patients with ejection fraction <40%

Exercise intolerance (<85% of predicted VO2 peak)

clinically stable for > 6 weeks, optimal medical treatment for > 6 weeks

Disqualifiers

Contra indications for cardiac exercise rehabilitation as per consensus guidelines and recommendations

Musculoskeletal disorders that hamper (progression in) strength training

Non-stabilized acute coronary syndrome

Current acute heart failure (decompensation)

Trial design

Design model

Parallel

Treatments tested in this trial

  • eccentric bike training

    Other intervention

    progressive following protocol, 10min

  • eccentric overload training

    Other intervention

    dynamic strength training + eccentric overload, progressive over time, 3sets\*10reps (15-20min)

  • aerobic treadmill training

    Other intervention

    aerobic training, progressive over time, 10 min

  • aerobic bike training

    Other intervention

    aerobic training, progressive following protocol, 10 min

  • traditional dynamic strength training

    Other intervention

    dynamic strength training, progression over time, 15-20 min

Treatment groups

3 Participants
are divided into 2 treatment groups
Group A: Eccentric strength training + cardioExperimental treatment 3 interventions
Group B: Traditional strength training + cardioActive comparator 3 interventions

Trial outcomes

Primary outcomes

1

1Repetition Maximum (=RM) leg press (kg)

One repetition maximum on leg press device Technogym BioCircuit. The patient is positioned correctly on the leg press (back supported, feet on platform in standardized way so that repeated tests are in the same position). The patiënt performes a maximal push, the load is automatically adjusted by the BioCircuit algorithm. The system identifies the maximum successful single push as the 1RM (kg).

Time frame
pre (baseline) + post (15 weeks)
2

1Repetition Maximum (=RM) Low Row (kg)

One repetition maximum on the low row device Technogym BioCircuit. The patient sits with chest supported, feet on the ground, and grips the handles with arms extended. The patiënt performes a maximal pull, the load is automatically adjusted by the BioCircuit algorithm. The system identifies the maximum successful single lift as the 1RM (kg).

Time frame
pre (baseline) + post (15weeks)
3

1Repetition Maximum (=RM) chest press (kg)

One repetition maximum on chest press device Technogym BioCircuit. The patient is positioned correctly on the chest press (back supported, feet on the ground in standardized way so that repeated tests are in the same position). The patiënt performes a maximal push, the load is automatically adjusted by the BioCircuit algorithm. The system identifies the maximum successful single push as the 1RM (kg).

Time frame
pre (baseline) + post (15weeks)
4

1Repetition Maximum (=RM) vertical traction (kg)

One repetition maximum on vertical traction device Technogym BioCircuit. The patient is positioned correctly on the vertical traction (back supported, feet on the ground in standardized way so that repeated tests are in the same position). The patiënt performes a maximal pull, the load is automatically adjusted by the BioCircuit algorithm. The system identifies the maximum successful single push as the 1RM (kg).

Time frame
pre (baseline) + post (15weeks)

Secondary outcomes

1

6mwt (m)

The 6-minute walk test (6MWT) assesses functional exercise capacity by measuring the distance walked in 6 minutes. It is performed on the same flat, straight corridor (50 meter) with marked turnaround points. The participant is instructed to walk as fast as possible at a self-paced speed. Standardized encouragement is given every minute. A timer is started at the beginning and stopped at 6 minutes. The total distance walked is measured in meters.

Time frame
pre (baseline) - post (15weeks)
2

Time up and go (s)

The participant starts seated in a standard chair (back against the chair, no armrests) On the command "go," the participant stands up, walks 3 meters, turns around, walks back, and sits down again. Timing starts on "go" and stops when the participant is seated again with the back against the chair). The test is performed 3 times (with 20seconds rest in between). The outcome is the mean time taken to complete the 3 tasks (seconds).

Time frame
pre (baseline) + post (15weeks)
3

VO2 peak (ml/kg/min)

VO₂peak is measured during a cardiopulmonary exercise test (CPET) on a cycle ergometer. The test is performed on a Lode Corival ergometer with breath-by-breath gas analysis via a Vyaire Medical system. After calibration of flow and gas analyzers, the subject is fitted with a mask and monitoring devices (ECG, BP). A short resting phase and unloaded cycling (warm-up) are performed. Workload then increases continuously using an individualized ramp protocol (e.g. 5-20 Watt/min - so small increase every 3-12 seconds). The same protocol is used in the pre and post test. The participant cycles at a constant cadence(≈60-70 revolutions/min) until volitional exhaustion. Expired gases are analyzed to determine oxygen uptake (VO₂) and carbon dioxide production (VCO₂). Strong verbal encouragement is given to reach maximal effort. VO₂peak is defined as the mean VO₂ value averaged over the final 30 seconds of exercise. Test termination follows symptom limitation or standard clinical safety criteria.

Time frame
pre (baseline) + post (15weeks)
4

maximal load (Watt)

Wattmax is determined during a CPET performed on a Lode Corival ergometer with monitoring via a Vyaire Medical system. After calibration of flow and gas analyzers, the subject is fitted with a mask and monitoring devices (ECG, BP). A short resting phase and unloaded cycling (warm-up) are performed. Workload then increases continuously using an individualized ramp protocol (e.g. 5-20 Watt/min - so small increase every 3-12 seconds). The same protocol is used in the pre and post test. The participant cycles at a constant cadence (≈60-70 revolutions/min) until volitional exhaustion. Wattmax is defined as the highest workload (in watts) achieved in the final stage. Strong encouragement is provided to achieve maximal effort.

Time frame
pre (baseline) + post (15weeks)

Other outcomes

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