Echocardiography-based Motion Integration and Management for Substrate Characterization and STAR Therapy in Ventricular Tachycardias

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorUniversity of Luebeck

About this trial

Prospective, observational, single center, pilot study to analyze the feasibility of motion and structural data integration in patients with ventricular arrhythmia by means of artificial intelligence for improved arrhythmogenic substrate characterization and motion management during stereotactic arrhythmia radioablation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age ≥ 18 years

Indication for catheter ablation of ventricular arrhythmias (ventricular fibrillation, ventricular tachycardia, premature ventricular contractions)

Indication for preprocedural contrast-enhanced cardiac computed tomography for cardiac structure characterization

Disqualifiers

Platelet count < 100,000 cells/mm3

BMI > 45 kg/m2 or < 18 kg/m2

Trial population

A total of 20 patients with indication for catheter ablation of ventricular arrhythmia (VA) (ventricular tachycardia (VT), ventricular fibrillation (VF), premature ventricular contraction (PVC)) and for preprocedural contract-enhanced cardiac computed tomography (CT) for cardiac structure characterization will be prospectively enrolled in the study. The therapeutic approach follows the current clinical standard.

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

20 Participants
are grouped into 1 trial group
Group A: VT Patients

Trial outcomes

Primary outcomes

1

Feasibility of algorithm training to achieve improved arrhythmogenic substrate characterization

The feasibility of training the artificial intelligence-based algorithm using the preprocedural contrast-enhanced cardiac computed tomography and optically-tracked 3D transthoracic echocardiography data to better define the ventricular arrhythmogenic substrate in patients exhibiting ventricular arrhythmias.

Time frame
1 month after complete data collection
2

Feasibility of algorithm training to improve the planning target volume definition for stereotactic arrhythmia radioablation therapy

The feasibility of training the artificial intelligence-based algorithm using the preprocedural contrast-enhanced cardiac computed tomography and optically-tracked 3D transthoracic echocardiography data to better define the planning target volume for stereotactic arrhythmia radioablation therapy

Time frame
1 month after complete data collection

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Luebeck

Lead sponsor

Institute for Robotics and Cognitive Systems, University of Luebeck, Germany

Collaborator