EEG Abnormalities as Predictor of Outcome in Pediatric Encephalopathy
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorAssiut University
About this trial
This prospective cohort study aims to evaluate the prognostic value of electroencephalographic (EEG) abnormalities in predicting poor clinical outcomes among children with encephalopathy admitted to Assiut University Children Hospital.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age from 1 month to 18 years
Clinical diagnosis of encephalopathy with altered level of consciousness
EEG performed within the first 48 hours of admission
Written informed consent from parents or legal guardians
Disqualifiers
Neonatal encephalopathy
Children with severe pre-existing neurological disability
Known epileptic patients
Incomplete clinical or EEG data
Trial population
Children aged 1 month to 18 years admitted with encephalopathy to the Pediatric Intensive Care Unit, Pediatric Neurology Unit, or Emergency Unit of Assiut University Children Hospital.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
147 Participants
are grouped into 1 trial groupGroup A: Single cohort: Children with encephalopathy
Trial outcomes
Primary outcomes
1
Poor neurological outcome at hospital discharge
Proportion of children with poor neurological outcome defined as Pediatric Cerebral Performance Category (PCPC) score ≥3 at hospital discharge.
Time frame
at 30 daysSecondary outcomes
1
Frequency of EEG abnormalities
Proportion of children with specific EEG abnormalities (diffuse background slowing, background suppression, burst suppression, absent reactivity, low-voltage activity, or electrographic seizures) recorded within the first 48 hours of admission.
Time frame
Within the first 48 hours of admission2
Predictive performance of EEG abnormalities for poor outcome
Sensitivity, specificity, and predictive values of specific EEG abnormalities for poor neurological outcome (PCPC ≥3) at hospital discharge.
Time frame
at 30 days3
Mortality
Proportion of children who die during hospital stay.
Time frame
at 30 days4
Duration of PICU stay
Length of stay in the pediatric intensive care unit in days.
Time frame
at 30 daysLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: