Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 75
SponsorTianjin Huanhu Hospital
About this trial
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Recruiting 200 patients with primary Parkinson's disease, aged less than 75 years old, regardless of gender, without prior brain injury, and with a history of brain surgery
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
DeviceWe observed the changes in cognitive function of patients before and after different brain stimulation treatments, and further compared the effects of different brain stimulation treatments on cognitive function of PD patients and the related mechanisms according to whether DBS surgery was performed or TMS therapy was given only according to the surgical indications.
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: Cognitive Impairment (CI) group and No Cognitive Impairment (NCI) group1 intervention
Trial outcomes
Primary outcomes
1
Montreal Cognitive Rating Scale(MoCA)
The Montreal Cognitive Rating Scale was used to assess the overall cognitive status of patients before and after treatment
Time frame
December 2023 to December 20262
verbal fluency test (VF)
VF test was used to assess frontal executive function and related language function
Time frame
December 2023 to December 2026Secondary outcomes
1
the third part of the Unified Parkinson's Disease Rating Scale (UPDRS III)
Measures motor symptoms and Higher scores indicate more severe impairment in motor function
Time frame
December 2023 to December 2026Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov