Effect and Safety of Fexofenadine Hydrochloride vs Placebo in Patients With Acute Myocardial Infaction: A Randomized Clinical Trial

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorSecond Affiliated Hospital, Zhejiang University, School of Medicine

About this trial

The purpose of this study was to evaluate the efficacy and safety of fexofenadine hydrochloride on the basis of standard treatment after PCI in STEMI patients.

Eligibility criteria

Qualifiers

Ages above 18;

Being able to verbally confirm understanding of the trial risks, benefits, and treatment options of receiving treatment with fexofenadine hydrochloride. He/she or his/her legal representative shall provide written informed consent before participating in the clinical trial.

Clinical symptoms: ischemic chest pain lasting for over 30 minites;

Elevated serum cTn: at least once higher than the upper limit of normal values (99th percentile of the reference upper limit);

Disqualifiers

Long term use of fexofenadine hydrochloride or other H1 receptor inhibitors;

Previously suffered from myocardial infarction or received coronary artery bypass grafting;

Patients with concomitant cardiomyopathy or valve disease;

History of severe renal failure, estimated glomerular filtration rate (eGFR) < 30ml/min;

Trial design

Treatments tested in this trial

  • Fexofenadine Hydrochloride
  • Placebo

Treatment groups

152 Participants
are divided into 2 treatment groups