Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Healthy, Recreationally Active Adults

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorLoughborough University

About this trial

The main aim of this study is to understand if chronic supplementation (12 weeks) of a milk fat globule membrane containing supplement, called bioactive whey protein concentrate, improves human muscle function greater than a placebo supplement within a cohort of healthy, recreationally active adults. Furthermore, we aim to investigate whether any potential benefits of milk fat globule membrane are influenced by age through the assessment of 2 distinct age subgroups (young and older). We hypothesise that neuromuscular function (strength and power) will increase from pre to post within the group that consumes bioactive whey protein concentrate but not the placebo group, with a greater increase in the older group compared to the young group.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18-30 or 60-75 years old

Male or female

Healthy with no contraindications to exercise

Classified as recreationally active (meet the government's guidelines for weekly physical activity - 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity)

Disqualifiers

Any injury, medical condition or symptom precluding the ability to complete strenuous exercise as identified by the health screen questionnaire and physical activity readiness questionnaire

Uncontrolled hypertension (blood pressure of 140/90 mmHg or higher) as identified by recording resting blood pressure

Neuromuscular or musculoskeletal disease

Occurrence of a severe injury to the lower limbs or back within the previous 6 months (time loss of > 21 days of normal activity)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Bioactive whey protein concentrate

    Dietary supplement

    Every day for 12 weeks, participants will mix 1 scoop of supplement with \~350ml of water and consume the resultant drink alongside their breakfast.

  • Whey protein isolate supplement

    Dietary supplement

    Every day for 12 weeks, participants will mix 1 scoop of supplement with \~350ml of water and consume the resultant drink alongside their breakfast.

Treatment groups

96 Participants
are divided into 2 treatment groups
Group A: Bioactive whey protein concentrate supplement groupExperimental treatment 1 intervention
Group B: Placebo groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Maximal voluntary isometric torque of the knee extensors

Assessed during maximal voluntary contractions (Nm)

Time frame
12 weeks

Secondary outcomes

1

Rate of torque development of the knee extensors

Assessed during explosive isometric contractions (Nm/s)

Time frame
12 weeks
2

Peak twitch torque (knee extensors)

(Nm)

Time frame
12 weeks
3

Time to peak twitch torque (knee extensors)

(ms)

Time frame
12 weeks
4

Half-relaxation time during twitch contractions (knee extensors)

(ms)

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Loughborough University

Lead sponsor

Volac International Limited

Collaborator