Effect of a Femoral Venting Hole on Embolic Load in Prophylactic Intramedullary Nailing

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorThe University of Texas Health Science Center, Houston

About this trial

The purpose of this study is to measure intraoperative embolic burden during prophylactic intramedullary nailing of impending femur fractures in patients treated with versus without venting, to find the association between embolic burden and intraoperative physiologic changes, measured using standard anesthesia monitors and charted data, to measure Immediate and short-term cardiopulmonary outcomes assessed during hospitalization and to assess procedure-related complications associated with venting

Eligibility criteria

Qualifiers

Diagnosis of an impending femur fracture requiring prophylactic intramedullary fixation

Long-term bisphosphonate use, or

Oncologic disease without radiographic evidence of cortical disruption

Ability to provide informed consent

Disqualifiers

Inability to obtain adequate intraoperative transthoracic echocardiography (TTE) imaging windows for visualization of right-sided cardiac structures

Inability to tolerate or safely undergo TTE monitoring per anesthesia determination

Any intraoperative technical limitation preventing reliable echocardiographic data acquisition

Trial design

Treatments tested in this trial

  • Femoral venting+ intramedullary nailing
  • Standard intramedullary nailing

Treatment groups

10 Participants
are divided into 2 treatment groups