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Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals

ConditionsMetabolically Unhealty ObeseDyslipidemiaDiabetes (DM)Resistance, InsulinObesity
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAndalas University

About this trial

This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity. The traditional Minangkabau foods used in this study consist primarily of coconut milk-based dishes, which contain coconut oil as a natural source of MCTs. The metabolic biomarkers assessed include body mass index (BMI), waist circumference, systolic and diastolic blood pressure, body fat percentage, fasting blood glucose levels, lipid profile, leptin concentrations, and DNA methylation of the leptin gene promoter. Based on these metabolic biomarker measurements, participants will be classified into metabolic obesity phenotypes, namely metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The researchers hypothesize that the provision of a low-calorie, MCT-rich diet based on traditional Minangkabau foods will have a significant effect on metabolic biomarkers and metabolic status in individuals with obesity.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Administrative staff of the Faculty of Medicine and the Faculty of Public Health, Andalas University, Padang, with obesity defined as a body mass index (BMI) ≥ 25 kg/m².

Willing to participate in the study by providing written informed consent.

Participants with obesity classified as Metabolically Unhealthy Obese (MUHO)

Disqualifiers

Did not come and could not be found at the time of research data collection

Unable to follow the dietary arrangements as set

Taking anti-diabetic or anti-lipid drugs

Use of contraceptives or hormonal drugs

Trial design

Design model

Parallel

Treatments tested in this trial

  • Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods

    Other intervention

    Participants in the intervention group received a nutritionally balanced low-calorie diet rich in medium-chain triglycerides (MCTs) derived from traditional Minangkabau foods. The dietary intervention was designed to provide an energy deficit of 500-600 kcal compared with participants' habitual daily intake. Assessments were conducted before and after the intervention period.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Intervention group (low-calorie diet rich in medium-chain triglycerides [MCTs] based on traditionaExperimental treatment 1 intervention
Group B: Control group (standard nutritionally balanced diet)No intervention 0 interventions

Trial outcomes

Primary outcomes

1

Change from baseline in body mass index (BMI).

BMI is calculated as body weight in kilograms divided by the square of height in meters (kg/m²).

Time frame
After 12 weeks
2

Change from baseline in waist circumference.

Waist circumference is measured around the abdomen at the level of the umbilicus.

Time frame
After 12 weeks
3

Change from baseline in body fat percentage

Body fat percentage is assessed using bioelectrical impedance analysis (BIA).

Time frame
After 12 weeks
4

Change from baseline in systolic and diastolic blood pressure

Blood pressure is measured using a digital tensimeter.

Time frame
After 12 weeks

Secondary outcomes

1

Change in metabolic status.

Metabolic status is classified into Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUHO) based on the number of metabolic abnormalities present. * MHO is defined as the presence of 0-1 metabolic abnormality. * MUHO is defined as the presence of ≥2 metabolic abnormalities. These metabolic abnormalities included elevated fasting blood glucose levels, increased blood pressure, enlarged waist circumference, elevated triglyceride levels, and reduced high-density lipoprotein (HDL) cholesterol levels.

Time frame
After 12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Andalas University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: