The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).
Married women aged 25-40;
Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);
Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.
Those who prepare for PGD;
Recipients of egg donors;
Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
patients with implantation failure due to known embryonic factors;
Parallel
acupuncture and IVF
DeviceAcupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.
sham acupuncture and IVF
DeviceSham acupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.
control group
Other interventionno acupuncture, only IVF
CPR
Clinical pregnancy rate
OPR
ongoing pregnancy rate
LBR
Live birth rate
Biochemical indexes
Biochemical indexes
Questionnaire score
Questionnaire score
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