About this trial
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity networks. In addition, it could potentiate the generalisation of effects to verbal and non-verbal communication skills, having a direct impact on patients' quality of life. This research is a prospective, randomized controlled, open-label, single-centre study. It is part of the management of patients with aphasia who have suffered a cerebral infarction and aims to evaluate the effect of combined language semantics/metacognition rehabilitation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
First cerebral infarction
Chronic phase (> 3 months)
Patient affiliated to a health insurance scheme
Usual french language
Disqualifiers
Contraindication to undergoing brain MRI
Cognitive impairment pre-existing stroke (CQI code > 3.4) (Law et al., 1995)
Chronic alcohol or drug abuse
Unstabilised psychiatric illness
Trial design
Parallel
Treatments tested in this trial
Semantic rehabilitation
BehavioralSemantic rehabilitation, consisting of validated lexico-phonological training exercises
Treatment groups
Trial outcomes
Primary outcomes
Performance at the "TD-264" untrained naming items task
The "TD-264 untrained naming items task" is a naming task of 264 images. Words corresponding to the images correctly named are "set success" and words wrongly named are "set treatment". The score at the task is composite : * reaction time allowing the speed of evocation to be measured will be measured with the Audacity software (https://audacity.fr/). * accuracy will be rated 1. quantitatively : number of "set success" 2. qualitatively : description of naming behaviors Scores are all from 0 to 264. 0 being the worst performance possible and 264 being the best performance possible.
Secondary outcomes
Reorganization of patients' functional connectivity maps compared to healthy volunteers
Reorganization of the functional connectivity of patients measured by the difference between the activation maps at the end of phase A and at the end of phase B, thanks to the acquisition of resting functional MRI sequences on the MRI dedicated to research (acquisition of resting-state MRI sequences)
Sponsors and contacts
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