Effect of Bilateral Maxillary Block on Intraoperative Remifentanil Consumption

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAtatürk Chest Diseases and Chest Surgery Training and Research Hospital

About this trial

The maxillary nerve block is a regional anesthetic technique targeting the sensory distribution of the maxillary nerve and is particularly preferred to provide analgesia in midfacial and maxillary surgical procedures. It has been used to optimize perioperative and postoperative pain control, reduce intraoperative opioid requirements, and support hemodynamic stability in procedures including septorhinoplasty, nasal bone osteotomies, nasal valve surgery, and endoscopic sinus surgery. This study aimed to compare the effects of the timing of bilateral maxillary nerve block administration (post-intubation vs. pre-extubation) on intraoperative remifentanil consumption and postoperative analgesia in patients undergoing septorhinoplasty.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

18 to 65 years old

American Society of Anesthesiologists (ASA) physical status I-II

Body mass index 18 to 30 kg/m2

Septorhinoplasty surgery

Disqualifiers

Patient refusing the procedure

Patients who have previously undergone nasal surgery

Chronic opioid or analgesic use

Patients with allergies to local anesthetics

Trial design

Design model

Parallel

Treatments tested in this trial

  • Preoperative Maxillary Block

    Drug

    After the intubation, the block procedure will be performed under ultrasound guidance using an infrazygomatic approach to access the pterygopalatine fossa. Prior to the procedure, the cheek region will be prepared in accordance with aseptic conditions. A linear ultrasound probe will be positioned over the infrazygomatic area to visualize the maxillary tuberosity, lateral pterygoid plate, coronoid process, and mandibular condyle. The following image optimization using the jaw-opening maneuver, the maxillary artery will be identified as an anatomical landmark, and a 50-mm block needle will be advanced into the pterygopalatine fossa using an in-plane technique. After confirmation of negative aspiration, a total of 4 mL of local anesthetic solution consisting of 2 mL of 0.5% bupivacaine and 2 mL of 2% lidocaine (Aritmal) will be injected on each side. The same procedure will subsequently be repeated contralaterally.

  • Postoperative Maxillary Block

    Drug

    At the end of the surgery, before the extubation, the block procedure will be performed under ultrasound guidance using an infrazygomatic approach to access the pterygopalatine fossa. Prior to the procedure, the cheek region will be prepared in accordance with aseptic conditions. A linear ultrasound probe will be positioned over the infrazygomatic area to visualize the maxillary tuberosity, lateral pterygoid plate, coronoid process, and mandibular condyle. The following image optimization using the jaw-opening maneuver, the maxillary artery will be identified as an anatomical landmark, and a 50-mm block needle will be advanced into the pterygopalatine fossa using an in-plane technique. After confirmation of negative aspiration, a total of 4 mL of local anesthetic solution consisting of 2 mL of 0.5% bupivacaine and 2 mL of 2% lidocaine (Aritmal) will be injected on each side. The same procedure will subsequently be repeated contralaterally.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Preoperative Maxillary BlockActive comparator 1 intervention
Group B: Postoperative Maxillary BlockActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Intraoperative remifentanil consumption

The amount of remifentanil that patients need to maintain anesthesia during the intraoperative period will be recorded.

Time frame
Intraoperative period

Secondary outcomes

1

Mean arterial pressure

Mean arterial pressure values will be recorded before anesthesia, before surgical incision, after surgical incision at the 5th, 30th, 60th, 90th, 120th, 150th, 180th, and 210th minutes, and after general anesthesia.

Time frame
Intraoperative period
2

Heart rate

Heart rate values will be recorded before anesthesia, before surgical incision, after surgical incision at the 5th, 30th, 60th, 90th, 120th, 150th, 180th, and 210th minutes, and after general anesthesia.

Time frame
Intraoperative period
3

Pain scores

Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at the 1st, 2nd, 6th, 12th, and 24th hours after surgery.

Time frame
First 24 hours after surgery

Other outcomes

Sponsors and contacts

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