Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorPaulista University

About this trial

Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

(1) diabetes and hypertension;

(2) inflammatory rheumatological, psychiatric, cardiovascular and/or respiratory disease;

(3) pre-existing injury restricting their ability to perform vigorous physical activities;

(4) having one or more predisposing risk factors for thromboembolism.

Disqualifiers

(1) have a health problem that does not allow them to continue;

(2) wish to leave the study;

(3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;

(4) not sign the consent form.

Trial design

Design model

Parallel

Treatments tested in this trial

  • BFR-80%

    Device

    Will perform the intervention with BFR using 80% of the total occlusion pressure (TOP) continuously for 20 minutes.

  • BFR-60%

    Device

    Will perform the intervention with BFR using 60% of the total occlusion pressure (TOP) continuously for 20 minutes.

  • BFR-10mmHg

    Other intervention

    Will perform the intervention with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes.

Treatment groups

80 Participants
are divided into 4 treatment groups
Group A: Blood flow restriction with 80% occlusionExperimental treatment 1 intervention
Group B: Blood flow restriction with 60% occlusionExperimental treatment 1 intervention
Group C: Blood flow restriction with 10 mmHg of occlusion pressurePlacebo comparator 1 intervention
Group D: ControlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Lower limb muscle power

Muscle power will be assessed through the Squat Jump test using a contact platform (Multisprint). Participants will begin in a 90° knee flexion position (verified with a goniometer), with hands on hips, and will perform a vertical jump without countermovement. Variables to be analyzed will include jump height, modified reactive strength index, jump power, and take-off moment.

Time frame
Change from baseline at 72 hours after exercise
2

Lower limb muscle function

Muscle function will be assessed through the single leg hop functional test sing a measuring tape in centimeters. The participant will be positioned standing on a flat surface, barefoot, and with their hands on their waist. They will be asked to perform a horizontal jump with the greatest possible reach using only one lower limb (test performed unilaterally). The contralateral limb will remain flexed without touching the ground during the execution. After the jump, the participant must maintain balance for at least two seconds without losing stability or moving the landing foot. The jump distance will be measured in centimeters from the toe of the supporting foot (before the jump) to the heel at the moment of landing, using a measuring tape.

Time frame
Change from baseline at 72 hours after exercise
3

Isometric strenght of quadriceps and hamstring muscle

The isometric peak torque of the quadriceps and hamstring will be measured using a digital handheld dynamometer (DD-300, Instrutherm). For the quadriceps strength assessment, the participant will be seated in a chair with their knee bent at 90° and instructed to push maximally against the dynamometer. To measure hamstring strength, the participant will be positioned in a prone position with their knee flexed at 90º and will be instructed to push maximally against the dynamometer. Three attempts will be performed with a 1-minute rest interval. The highest value will be used for analysis.

Time frame
Change from baseline at 72 hours after exercise
4

Muscle soreness and pain threshold

Muscle soreness will be assessed using a Numeric Pain Rating Scale (0-10). Pain threshold will be measured with a pressure algometer (FPX 50/220; Wagner) at four sites: biceps femoris and rectus femoris. Measurements will be recorded in kgf and will not exceed 2.55 kgf.

Time frame
Change from baseline at 72 hours after exercise

Secondary outcomes

Other outcomes

1

Occlusion pressures (AOP)

To determine the AOP, the Doppler equipment transducer will be used, which will be positioned over the posterior tibial artery to capture the auscultatory pulse. A blood pressure cuff will be fixed to the participant's thigh close to the region of the inguinal fold of the dominant limb, and then with the inflatable region of the cuff on the medial portion of the thigh covering the femoral artery, it will be progressively inflated, waiting 15 seconds every 30 mmHg until the point at which the auscultatory pulse of the tibial artery is interrupted.

Time frame
Baseline

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