Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder

Manics symptoms

The primary endpoint will be the change of total score of the Young Mania Rating Scale (YMRS) from baseline to day 10. The YMRS is a checklist of 11 items that are ranked on a scale of 0-4 or 0-8, the latter anchoring given to the four items which can be rated even with patients with poor cooperation. The score range therefore is between 0 and 60. This scale is classically used to assess the effectiveness of the treatment on manic symptoms. This is a clinical interview scale to assess the severity of manic states primarily used for research and it is designed to measure the severity of manic states, it can help guide clinicians on treatment planning and progress. The investigators define a score of at least 20 points on the YMRS (\> 20) to identify a manic state and the lower the score, the more the patient is in a state of euthymia (scale \<2).

Sleep quality

The investigators aim to assess the sleep quality for each participant by the Pittsburgh Sleep Quality Index (PSQI) and hypothesize that the patients receiving the intervention will have a better sleep quality. The scale assesses a broad range of sleep domains and consists of 19 self-rated questions that measure seven components of sleep that are scored from 0 to 3: sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleep medication and daytime dysfunction. The global score is the combination of the seven sub-scores and ranges therefore from 0 to 21, with higher scores for worse sleep quality; the cut-off point to define "poor sleepers" is \>5.

Psychotics symptoms

The investigators aim to assess the presence or absence of psychotics symptoms by the Positive and Negative Syndrome Scale (PANSS). The scale has mostly been used to inventory, grade and follow the symptoms in schizophrenia. It quantifies positive symptoms, which refer to an excess or distortion of normal functions (e.g., hallucinations and delusions), and negative symptoms, which represent a diminution or loss of normal functions. The PANSS is composed of 3 subscales: Positive Scale, Negative Scale, and General Psychopathology Scale. Each subscale is rated with 1 to 7 points ranging from absent to extreme. The range for the Positive and Negative Scales is 7-49, and the range for the General Psychopathology Scale is 16-112

Kinectics of the decrease of manics symptoms

The investigators aim to assess the kinetics of the decrease of manics symptoms for each participtant and hypothesize that participants receiving the intervention will have a faster decrease in the Young Mania Rating Scale (YMRS).

Impact on maximal administred antipsychotic medication dosage

The investigators aim to record the dosage of antipsychotic treatment for each patient and hypothesize that participants receiving the intervention will have lower dosage.

Depressive symptoms

The investigators aim to assess the incidence and severity of depressive symptoms (in manic episode) or aggravation of depressive symptoms (in manic episode with mixed features) by the Montgomery-Asberg Depression Rating Scale (MADRS). The rating should be based on a clinical interview moving from broadly phrased questions about symptoms to more detailed ones which allow a precise rating of severity. Each item has a severity scale from 0 to 6, with higher scores reflecting more severe symptoms. Ratings can be added to form an overall score (from 0 to 60). This is our cut-offs : scores of 0-6 indicate an absence of symptoms; 7-19 represent mild depression; 20-34 moderate; 35-60 indicate severe depression.

Side effects

All adverse effects will be rigorously monitored during the whole study for each participant. Number of participants with treatment-related adverse events will be recorded if present.