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Effect of CoQ10 on the Endocrine Function of Skeletal Muscle

ConditionsIschemic PreconditioningCoenzyme Q DeficiencyExercise Training
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age21-29
SponsorMedical University of Gdansk

About this trial

Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles.

In the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

gender (males only),

not taking medication during the study,

good health (no concomitant injuries),

negative history of cardiovascular disorders, autonomic nervous system, mental disorders, cerebrospinal injuries and other diseases that may directly affect the results obtained.

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • CoQ10 supplementation

    Dietary supplement

    Young men training endurance running will be supplemented with CoQ10

  • Ischemic preconditioning training

    Procedure/Surgery

    Young men training endurance running will undergo IPC training

  • IPC training combined with CoQ10 supplementation

    Dietary supplement

    Young men training endurance running will undergo IPC training combined with CoQ10 supplementation

  • Sham IPC combined with placebo

    Dietary supplement

    Young men training endurance running will undergo sham IPC training combined with placebo supplementation

Treatment groups

100 Participants
are divided into 4 treatment groups
Group A: Supplemented population 300mgPlacebo comparator 1 intervention
Group B: Training and IPC preconditioningExperimental treatment 1 intervention
Group C: Control group (placebo)Placebo comparator 1 intervention
Group D: IPC control groupSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

The effects of IPC on physical performance

IPC training will be combined with endurance exercise and VO2max and serum Lactate will be measured

Time frame
8 weeks
2

The effects of CoQ10 supplementation on physical performance

CoQ10 supplementation combined with endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response will be measured

Time frame
8 weeks
3

The effects of CoQ10 supplementation and IPC on physical performance

CoQ10 supplementation combined with IPC and endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response, ulic acid will be measured

Time frame
8 weeks

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medical University of Gdansk

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: