Effect of Different Root Canal Sealers on Oxidative Stress Markers
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
Sponsorbengi gülgü
About this trial
The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are:
Is there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment?
Researchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment.
* Participants will be informed about all procedures before starting the clinical process. * Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment. * Participants will be informed in writing about the treatment procedure before starting the clinical process. * Participants are expected to sign the informed consent form on a voluntary basis.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Systemically healthy, ASA1 patients,
Phase 1 periodontal treatment was performed,
Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth,
The lesion measured <2 cm on radiographic evaluation,
Disqualifiers
Patients who have used antibiotics in the last three months and analgesics in the last two weeks
Patients who smoke and/or abuse alcohol
Patients younger than 18 years or older than 45 years,
Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6)
Trial design
Design model
Parallel
Treatments tested in this trial
Root Canal Treatment and Sample Collection
Other interventionSingle session root canal treatment procedure will be performed with VDW Gold Reciproc device and reciprocal files (Endo T-Must, Dentac, Turkey). Endodontium Samples will be collected from each patient's root canal, with 15 Hedström files (Dentsplay).
PAI Score Comparasion
Diagnostic testPAI scores of the patients will be determined with periapical films taken before treatment and compared with oxidative stress markers before and after treatment for the epoxyamine group and bioceramic group.
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: 1- Bioceramic GroupExperimental treatment 2 interventions
Group B: 2- Epoxy amine GroupExperimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Changes in biochemically measured oxidative stress markers at 30th day in patients treated with epoxyamine/bioceramic root canal pastes.
oxidative stress markers (myeloperoxidase, 8-epi, total oxidant status, total antioxidant status, oxidative stress index, malondialdehyde) will be measured and compared biochemically in saliva samples taken from the patients on the first and thirtieth day.
Time frame
three month aproximately2
Comparison of the changes observed in biochemically measured oxidative stress markers of patients in the bioceramic group and patients in the epoxyamine group at day 1 and day 30
results of oxidative stress measurement obtained from bioceramic group and epoxyamin group will be compared. comparsion will be performed with biochemical kits for saliva samples.
Time frame
three month aproximatelySecondary outcomes
1
Investigation of the relationship between biochemically measured oxidative stress markers from endodontium and initial saliva samples obtained from all patients and PAI score determined by periapical films
results of PAI and oxidative stress markers measured with biochemical kits will be compromised.
Time frame
three months aproximatelySponsors and contacts
Click on the lead sponsor to view all of their trials.
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Lead sponsor
Ordu University
Sponsor institution
Source ClinicalTrials.gov