Effect of Different Sex Hormone Profiles for the Response to Physical Training
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-35
SponsorUniversity of Aarhus
About this trial
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
BMI 19-25
Disqualifiers
Training more than 2 times per week
Smoking
Pregnancy
Taking any medications known to affect the outcome parameters
Trial design
Design model
Parallel
Treatments tested in this trial
Physical training
BehavioralAerobic and resistance training three times per week. Two supervised training sessions.
Treatment groups
60 Participants
are divided into 3 treatment groupsGroup A: Non-hormonal contraception usersActive comparator 1 intervention
Group B: IUD usersExperimental treatment 1 intervention
Group C: Progestin only pill usersExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Muscle mass
Muscle mass measured by DXA
Time frame
4 months2
Fat free mass
Fat free mass measured by DXA
Time frame
4 monthsSecondary outcomes
1
Muscle fiber type measured by histochemical staining
Muscle fiber type measured by histochemical staining
Time frame
4 months2
Protein expression in skeletal muscle tissue
Expression of Muscle protein signaling markers for muscle protein degradation and synthesis pathways
Time frame
4 months3
Adipose tissue sex hormone receptors
Adipose tissue sex hormone receptors
Time frame
4 months4
Resting metabolic rate
Resting metabolic rate measured via indirect calorimetry
Time frame
4 monthsSponsors and contacts
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Source ClinicalTrials.gov