Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-9
SponsorUniversidade Ceuma

About this trial

Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. The amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of CPP-ACPF dental mousse on deproteinized hypomineralized enamel.

Eligibility criteria

Qualifiers

Children with at least one permanent molar without MIH.

At least two permanent molars with mild MIH lesions (demarcated opacities without structural loss)

Lesions may be with or without sensitivity

Lesions cream-white or yellowish in color

Disqualifiers

Visible bacterial biofilm

Enamel malformations associated with syndromes

Amelogenesis imperfecta

Fluorosis

Trial design

Treatments tested in this trial

  • Sodium hypochlorite 5.25%
  • CPP-ACPF

Treatment groups

54 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Universidade Ceuma

Lead sponsor

Fundação de Amparo à Pesquisa e Desenvolvimento Científico do Maranhão

Collaborator