Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. The amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of CPP-ACPF dental mousse on deproteinized hypomineralized enamel.
Children with at least one permanent molar without MIH.
At least two permanent molars with mild MIH lesions (demarcated opacities without structural loss)
Lesions may be with or without sensitivity
Lesions cream-white or yellowish in color
Visible bacterial biofilm
Enamel malformations associated with syndromes
Amelogenesis imperfecta
Fluorosis
Single group
Sodium hypochlorite 5.25%
DrugSodium hypochlorite is a proteolytic substance that interferes with the cellular metabolism of proteins.
CPP-ACPF
DrugCasein is a milk-derived protein that, during enzymatic digestion in the mouth, is converted into a casein phosphopeptide (CPP) molecule. CPP is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, keeping them in an amorphous form. Thus, CPP-ACPF functions as a reservoir of calcium phosphate.
Mineralization of MIH lesions
The measurements will be taken using a spectrophotometer (Vita Easyshade) to assess tooth brightness before and after treatment
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Universidade Ceuma
Lead sponsor
Fundação de Amparo à Pesquisa e Desenvolvimento Científico do Maranhão
Collaborator
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