About this trial
Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. The amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of CPP-ACPF dental mousse on deproteinized hypomineralized enamel.
Eligibility criteria
Qualifiers
Children with at least one permanent molar without MIH.
At least two permanent molars with mild MIH lesions (demarcated opacities without structural loss)
Lesions may be with or without sensitivity
Lesions cream-white or yellowish in color
Disqualifiers
Visible bacterial biofilm
Enamel malformations associated with syndromes
Amelogenesis imperfecta
Fluorosis
Trial design
Treatments tested in this trial
- Sodium hypochlorite 5.25%
- CPP-ACPF
Treatment groups
Sponsors and collaborators
Universidade Ceuma
Lead sponsor
Fundação de Amparo à Pesquisa e Desenvolvimento Científico do Maranhão
Collaborator