Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

ConditionsHypoglycemia Type1diabetes

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-45

SponsorUniversity of Cincinnati

About this trial

Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

males and females of any race or ethnicity

non-obese (BMI < or = to 30)

have a diagnosis of type 1 diabetes

C-peptide negative

Disqualifiers

pregnant women

cigarette smoking

Taking inflammation-targeting steroids (e.g., prednisone).

Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).

Trial design

Design model

Crossover

Treatments tested in this trial

Fasting
Other intervention
Subjects remain fasted prior to insulin-induced hypoglycemia.
Feeding
Other intervention
Subjects eat a normal breakfast and lunch prior to insulin-induced hypoglycemia.

Treatment groups

10 Participants

are divided into 2 treatment groups

Group A: FastingExperimental treatment 1 intervention

Group B: FeedingExperimental treatment 1 intervention

Trial outcomes