Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorCukurova University
About this trial
This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis.
Participants with obesity and periodontitis will be divided into two groups: those who have been using a GLP-1 RA for at least 3 months and those who are not using any medication for obesity. All participants will receive the same non-surgical periodontal treatment, including oral hygiene instruction, scaling, and root planing.
Periodontal clinical measurements and gingival crevicular fluid samples will be collected before treatment and at 3 and 6 months after treatment. The study will compare changes in periodontal health and inflammatory markers between the two groups to determine whether GLP-1 RA use is associated with periodontal health and the response to non-surgical periodontal therapy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age between 18 and 65 years
Body mass index (BMI) ≥25 kg/m²
Presence of at least 20 functional teeth
Diagnosis of periodontitis
Disqualifiers
Age between 18 and 65 years
Body mass index (BMI) ≥25 kg/m²
Presence of at least 20 functional teeth
Diagnosis of periodontitis
Trial design
Design model
Parallel
Treatments tested in this trial
non-surgical periodontal therapy
Procedure/SurgeryAll participants will receive oral hygiene instructions, including instruction in the modified Bass toothbrushing technique. Non-surgical periodontal therapy will be performed under local anesthesia in two sessions and will include full-mouth subgingival instrumentation and scaling and root planing using ultrasonic instruments and Gracey curettes. No adjunctive antimicrobial agents will be used.
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: Title: GLP-1 Receptor Agonist GroupActive comparator 1 intervention
Group B: Control GroupPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Probing Depth
Time frame
Baseline, 3 months- 6 monthsSecondary outcomes
1
Gingival Index
Time frame
Baseline, 3months- 6 monthsLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: