Male Accessory Glands Inflammations (MAGI) include inflammatory diseases involving seminal vescicles and the prostate. Patients suffering from them present an impaired fertility because of seminal duct obstruction and alterations of the rheologic and functional parameters of semen, induced by direct microbiological action as well as inflammatory and oxidative damage. Inflammation in seminal plasma can be detected and measured by dosing of inflammatory molecules such as SuPAR and ST2. Treatment of MAGIs include specific antibiotic therapy in addition to use of anti-inflammatory nutraceutics. Deprox HP is a nutraceutic containing GraminexTM, a compound made of pollen extracts of rye, mais and timothy. To investigate its efficacy, we evalued seminal parameters, inflammatory and oxidative molecules in seminal plasma and clinical and ultrasonographic features of male accessory glands before and after 3 months of treatment in 20 patients taking Deprox HP and 20 patients undergoing treatment with palmitoilethanolammide, bromelin and horse chestnut extract.
Male patients with a diagnosis of MAGI based on clinical and/or ultrasonographic criteria.
History of cryptorchidism, orchitis, testicular torsion or trauma,
Hypogonadism,
Occupational chemical exposure,
Y chromosome microdeletions, karyotype abnormalities and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mutations,
Parallel
Deprox_HP
Other interventionUse of nutraceutic based on a compound of pollen extracts from pollen, mais and timothy
Peacist
Other interventionUse of a nutraceutic based on palmitoilethanolamide + Bromelin + Horse Chestunt extract
Modifications of number of spermatozoa
Modifications of the number of spermatozoa in Millions
Modification of sperm motility
Modification of sperm progressive motility in %
Modifications of number of typical forms
Modifications of number of typical forms in %
Modifications of seminal inflammatory parameters
Modifications of seminal inflammatory parameters ST2 and SuPAR, both expressed in ng/mL
Modifications of seminal oxidative parameters
Modifications of reactive oxygen species expressed in mEq
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