Effect of Individualized PEEP on Postoperative Pulmonary Complication in Bariatrics
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16+
SponsorAin Shams University
About this trial
Ventilation with low tidal volume and high PEEP (positive end expiratory pressure) has been shown to improve oxygenation in patients with ARDS (acute respiratory distress syndrome). In obese patients undergoing laparoscopic bariatric surgeries, the risk of postoperative pulmonary complications (PPCs) increases significantly with general anesthesia. Previous studies have shown that protective lung ventilation strategies could improve intraoperative oxygenation and lung mechanics.
In this study would compare the effect of optimum individualized high PEEP versus standard PEEP - on postoperative pulmonary complications
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients were eligible for participation if the met the following criteria
Age between 18 and 60 years old.
Body mass index > 40
Laparoscopic bariatric elective surgery under general anesthesia.
Disqualifiers
Previous lung surgery
ASA status III or IV.
Moderate to severe obstructive or restrictive lung disease .
Persistant intraoperative hemodynamic instability .
Trial design
Design model
Parallel
Treatments tested in this trial
titated PEEP to best static compliance
Other interventionthe Intraoperative PEEP will be titrated to best static compliance for each patient
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: titrate PEEPExperimental treatment 1 intervention
Group B: standardActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
postoperative pulmonary complication
pneumonia-atelactasis-bronchospasm-respiratory failure
Time frame
postoperative 10 days after surgerySecondary outcomes
1
Pulmonary functions test
This test includes these values :FVC (forced vital capacity ) FEV1( forced expiratory volume in one sec ) FEV1% and FVC%
Time frame
postoperative 1st , 3rd and 5th daySponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov