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Effect of Inspiratory Muscle Training on Diaphragm Function in COPD Patients

ConditionsChronic Obstructive Pulmonary Disease (COPD)Diaphragm Dysfunction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-59
SponsorUniversitas Padjadjaran

About this trial

This study investigates the effect of threshold inspiratory muscle training on diaphragm thickness and diaphragm excursion, measured using ultrasonography, in patients with stable chronic obstructive pulmonary disease (COPD).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with a COPD GOLD stage 2

Age 40-59 years

Maximal Inspiratory Pressure (MIP) value of less than 70 cmH₂O or below the lower limit of normal for their age and gender

Clinically stable for at least 4 weeks prior to the study

Disqualifiers

Patients with contraindications to Inspiratory Muscle Training or spirometry (e.g., recent thoracic or abdominal surgery, pneumothorax, or history of spontaneous pneumothorax).

Patients participating in other structured respiratory muscle training or pulmonary rehabilitation programs concurrently that could confound the results

Patients undergoing other therapies that may affect diaphragmatic muscle measurement results, such as electrical diaphragmatic stimulation

Trial design

Design model

Single group

Treatments tested in this trial

  • Threshold Inspiratory Muscle Training

    Other intervention

    Threshold inspiratory muscle training performed using a threshold loading device to improve inspiratory muscle strength. Training is conducted once daily, five times per week for 6 weeks, with intensity starting at 30% and progressively increasing up to 50% of maximal inspiratory pressure (MIP) based on patient tolerance.

  • Philips Respironics Threshold IMT device

    Device

    A threshold loading device used to provide inspiratory resistance during inspiratory muscle training

Treatment groups

15 Participants
are divided into 1 treatment group
Group A: Threshold Inspiratory Muscle TrainingExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Diaphragm Thickness (cm)

Diaphragm thickness reflects the structural characteristics of the diaphragm muscle and is measured at end-inspiration and end-expiration using ultrasonography. The values are expressed in centimeters (cm).

Time frame
Baseline to Week 6
2

Diaphragm Excursion (cm)

Diaphragm excursion represents the vertical movement of the diaphragm during the respiratory cycle, reflecting diaphragmatic mobility and function. Measurements are obtained using ultrasonography and expressed in centimeters (cm).

Time frame
Baseline to Week 6

Secondary outcomes

1

Forced Vital Capacity (FVC)

Forced Vital Capacity (FVC) is assessed using spirometry and measured in liters (L). It represents the total volume of air that can be forcibly exhaled after a full inhalation and reflects overall lung capacity.

Time frame
Baseline to Week 6
2

Forced Expiratory Volume in one second (FEV1)

Forced Expiratory Volume in one second (FEV1) is measured using spirometry and expressed in liters (L). It represents the volume of air exhaled in the first second of a forced expiration.

Time frame
Baseline to Week 6
3

Peak Expiratory Flow (PEF)

Peak Expiratory Flow (PEF) is measured using spirometry and expressed in liters per second (L/s). It reflects the maximum airflow achieved during forced expiration and indicates airway function.

Time frame
Baseline to Week 6

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Universitas Padjadjaran

Lead sponsor

Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: