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Effect of Intravenous Magnesium on Postoperative Systemic Inflammatory Response in Patients Undergoing Colorectal Cancer Surgery

ConditionsPost Operative Inflammatory Marker LevelsPost Operative Pain
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-75
SponsorAin Shams University

About this trial

The aim of this study is to detect the effect of intraoperative intravenous magnesium sulfate on postoperative systemic inflammatory response by serum inflammatory parameters as CRP, WBCS and neutrophil count.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA I and ASA II.

Age (35yrs - 75yrs).

Patients undergoing open colorectal cancer surgery.

Sex: Both sexes.

Disqualifiers

Renal impairment (Glomerular Filtration Rate < 60 ml\min).

Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR < 50 bpm) and atrioventricular block (first, second and third degree).

Allergy to study drug (MgSO4).

Patient refusal to precipitate in this study.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Magnesium sulfate (MgSO4)

    Drug

    After the induction of anesthesia, the patients will receive loading intravenous magnesium sulfate (50mg/kg over 20 minutes) and maintenance (15mg/kg/hr) till the end of surgery.

  • Normal Saline

    Drug

    The patients will receive the same normal saline volume for loading and maintenance.

Treatment groups

52 Participants
are divided into 2 treatment groups
Group A: study group (magnesium sulfate group)Active comparator 1 intervention
Group B: control groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

postoperative white blood cell count (WBC)

Assess effect of intravenous magnesium sulfate on postoperative inflammation by serum inflammatory marker as WBCS.

Time frame
inflammatory markers will be measured at 2 time points: 12 and 36 hours after surgery.

Secondary outcomes

1

postoperative C-reactive protein (CPR)

Effect of intravenous magnesium sulfate on postoperative serum C-reactive protein level.

Time frame
during 36 hrs postoperative.CRP will be measured at 2 time points: 12 and 36 hours after surgery.
2

postoperative neutrophil count

Effect of intravenous magnesium sulfate on postoperative neutrophil count.

Time frame
12 and 36 hours after surgery.
3

Time to recovery from anesthesia

time from discontinuation of anesthetic drug administration and completion of the surgical procedure until extubation.

Time frame
immediately after surgery
4

Postoperative pain intensity

Postoperative pain intensity assessed using the visual Analog Scale (VAS).

Time frame
During the first 36 hours postoperatively.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov
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