Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil

ConditionCholecystectomy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-85

SponsorAssaf-Harofeh Medical Center

About this trial

Analgesia is one of the pillars of anesthesia. One of the common opiates for pain relief, with a short half-life, is Remifentanil. However, following Remifentanil treatment an increased sensitivity to pain \[hyperalgesia\] appears. The aim of the study is to compare the effects between complementary treatments, like Ketalar and Dexmedetomidine, in preventing increased sensitivity to pain after Remifentanil treatment

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Patients with sensitivity to the anesthetic

Patients with chronic pain who are in regular treatment

Urgent surgery

Patients with ischemic heart disease

Trial design

Design model

Parallel

Treatments tested in this trial

Ketalar
Drug
a dissociative anesthetic used medically for induction and maintenance of anesthesia
Dexmedetomidine
Drug
an agonist of α2-adrenergic receptors in certain parts of the brain used for sedation

Treatment groups

90 Participants

are divided into 2 treatment groups

Group A: KetalarActive comparator 1 intervention

Group B: DexmedetomidineActive comparator 1 intervention

Trial outcomes

Primary outcomes

Pain Level

A record of pain level will be made using the Visual Analogue Scale. The score is determined by marking on 10-cm line between 0 - "no pain" to 10 - "the highest pain".

Time frame

Up to two hours after the end of the anesthesia process

Pain killer consumption

Treatment with morphine for pain relief

Time frame

Up to two hours after the end of the anesthesia process

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assaf-Harofeh Medical Center

Lead sponsor

Source ClinicalTrials.gov

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