Effect of Knee Position on Muscle Loss During Leg Immobilization
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorWageningen University
About this trial
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.
Eligibility criteria
Qualifiers
Healthy males and females
Aged from 18-40 years at the time of signing informed consent
18.5 < BMI < 30 kg·m-2
Must be willing and able to communicate and participate in the whole study
Disqualifiers
Smoking
Diabetes (Type 1, Type 2, or genetic form of diabetes)
Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
Chronic use of any prescribed or over the counter pharmaceuticals that may modulate muscle protein metabolism (excluding oral contraceptives and contraceptive devices).
Trial design
Treatments tested in this trial
- Knee immobilization brace (0°) for 5 days
- Knee immobilization brace (60°) for 5 days
Treatment groups
30 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Wageningen University
Lead sponsor
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborator
Source ClinicalTrials.gov