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Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

ConditionsSystolic HypertensionPregnancy RelatedDiastolic HypertensionCardiac Output, LowCardiac Output, High
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-45
SponsorMarshall University

About this trial

The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital

English speaking

18-45 years old.

Willing to provide informed consent

Disqualifiers

Non-English speaking patients, patients

<18 years old or >45 years old

Not willing or able to provide consent

Gestational age >15 weeks

Trial population

Patients presenting to the Maternal Hypertension Center at Cabell Huntington Hospital. Consent will be obtained prior to enrollment. Patient age range will be from age 18 to approximately 45.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Labetalol

    Drug

    Beta blocker

  • Atenolol

    Drug

    Beta blocker

  • Nifedipine

    Drug

    Calcium channel blocker

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Beta blockade2 interventions
Group B: Nifedipine1 intervention

Trial outcomes

Primary outcomes

1

Systolic blood pressure

Measured in mmHg

Time frame
Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
2

Diastolic blood pressure

Measured in mmHg

Time frame
Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
3

Mean arterial pressure

Measured in mmHg

Time frame
Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
4

Heart rate

Measured in beats per minute

Time frame
Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Marshall University

Lead sponsor

Source ClinicalTrials.gov
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