This randomized controlled clinical study aims to evaluate the effect of local application of 1% metformin gel on implant stability and peri-implant bone density. Patients requiring dental implants will be randomly allocated into two groups: a control group and a test group receiving metformin gel. Implant stability will be assessed using resonance frequency analysis, and bone density will be evaluated using CBCT imaging. The outcomes will be compared over a follow-up period to determine the effectiveness of metformin in enhancing osseointegration
1) Patients age at least 18 years old. 2) Patient with partial edentulous teeth bounded areas that need dental implant for teeth replacement.
None
Parallel
Metformin gel, 1%
DrugA 1% metformin gel is locally applied directly into the implant osteotomy site immediately prior to implant placement. The gel is confined to the surgical site and is not systemically administered. This protocol is designed to evaluate the localized effect of metformin on implant stability and peri-implant bone density during the healing period.
Standard Implant Placement
Other interventionImplant placement performed following the standard surgical protocol without any local pharmacological application in the osteotomy site.
Peri implant bone density
Peri-implant bone density will be evaluated using Cone Beam Computed Tomography (CBCT).
implant stability
Implant stability will be assessed using resonance frequency analysis (RFA) and expressed as Implant Stability Quotient (ISQ) values. Measurements will be taken at baseline, immediately after implant placement ,6 weeks, and 3 months postoperatively.
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