The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\[s\] it aims to answer are:
1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise? 2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise? 3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise? 4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise?
Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks
Frailty level is in pre-frailty
MoCA INA score above 18
Domicile in Bandung City
Willing to participate in the study after informed consent
There is a hearing impairment that may prevent the subject from receiving verbal instructions
There is uncorrected visual impairment
There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables
Subjects received other rehabilitation programs
Single group
EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Other interventionExercise training that consists of flexibility, aerobic, balance and strengthening regime. The exercise given three times a week, for 12 weeks.
Change From Baseline in Level of Global DNA Methylation in 12 Weeks
Global DNA Methylation will be measured twice using ...
Change From Baseline in Level of Growth Deficiency Factor (GDF15) in 12 Weeks
GDF15 will be measured using blood plasma with Enzyme Linked Immuno Assay (ELISA), expected GDF value that show improvement that it will be decreased
Change From Baseline in Level of Lamin A (Cyclic Osteo Progenitor) COP in 12 Weeks
Lamin A COP will be measured with flow cytometry from Peripheral Blood Mononuclear Cells (PBMC), the value that shows improvement has a lesser lamin A COP population
Change From Baseline in Level of Frailty in 12 Weeks
Level of Frailty is measured using Fried's Frailty Phenotype with range 1-5 with 5 is the worst level of frailty. Fried's frailty measured with five components that are unintentional weight loss, muscle weakness, exhaustion on activity, slow gait and low physical activity.
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