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Effect of Morus Nigra Mouthwash on Gingivitis Treatment

ConditionGingivitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorInonu University

About this trial

The aim of this study is to evaluate the clinical, microbiological, and biochemical effects of Morus nigra (black mulberry) mouthwash when used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with generalized gingivitis. Participants will be randomly assigned to two groups: one receiving SRP only, and the other receiving SRP plus Morus nigra mouthwash twice daily for 14 days. Clinical parameters, cytokine levels in gingival crevicular fluid (TNF-alpha, IL-1beta, IL-10), and subgingival bacterial load will be assessed at baseline, 1 month, and 3 months.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of generalized gingivitis (Gingival Index > 1).

Presence of at least 20 natural teeth.

Systemically healthy individuals.

Ability to provide informed consent.

Disqualifiers

Smoking or use of tobacco products.

Presence of periodontitis (no clinical attachment loss).

Use of antibiotics or anti-inflammatory drugs in the last 6 months.

Pregnancy or lactation.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Scaling and Root Planing

    Procedure/Surgery

    Mechanical removal of dental plaque and calculus from the tooth surfaces

  • Morus Nigra Mouthwash

    Dietary supplement

    Morus nigra extract based mouthwash, used 2 times a day for 14 days

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Control GroupActive comparator 1 intervention
Group B: Test GroupExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Changes in Gingival Index (GI)

Gingival inflammation will be assessed using the Loe and Silness Gingival Index. Higher scores indicate more severe inflammation.

Time frame
Baseline, 1 month, and 3 months.

Secondary outcomes

1

Cytokine levels in Gingival Crevicular Fluid (GCF)

Evaluation of TNF-alpha, IL-1beta, and IL-10 levels in GCF using ELISA method.

Time frame
Baseline, 1 month, and 3 months
2

Subgingival Bacterial Load

Detection and quantification of total bacterial load and specific periodontopathogenic bacteria using Real-time PCR

Time frame
Baseline, 1 month, and 3 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Inonu University

Lead sponsor

Source ClinicalTrials.gov
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