Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia

ConditionAsthenozoospermia

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexMale

Age20-50

SponsorMst.Sumyara Khatun

About this trial

The goal of this clinical trial is to learn if drug Pentoxifylline plus Coenzyme Q10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Pentoxifylline plus Coenzyme Q10. The main questions it aims to answer are:

Does drug Pentoxifylline plus Coenzyme Q10 increase the motility of sperm in participants? What medical problems do participants have when taking drug Pentoxifylline plus Coenzyme Q10 ? Researchers will compare drug Pentoxifylline plus Coenzyme Q10 combination to Coenzyme Q10 alone to see if drug Pentoxifylline plus Coenzyme Q10 combination works better.

Participants will:

Experimental Group:Pentoxifylline 400mg twice dailyand Coenzyme Q10 100mg twice daily for 3 months.

Comparator Group: Coenzyme Q10 100mg twice daily for 3 months Visit the clinic after three months of treatment for checkups and tests

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021.

Age 20-50 years.

Disqualifiers

Severe oligoasthenoteratozoospermia

Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.

Antioxidants supplmentation in the last 3 months

Drug, alcohol or substance abuse, psycho-sexual abnormalities.

Trial design

Design model

Parallel

Treatments tested in this trial

Coenzyme Q 10
Dietary supplement
Participants will receive Coenzyme Q10 100 mg twice daily for 3 months
Pentoxifylline 400 MG Oral Tablet
Combination product
Participants will receive pentoxifylline 400mg twice daily plus coenzyme Q10 100mg twice daily for 3 months

Treatment groups

56 Participants

are divided into 2 treatment groups

Group A: Experimental (PTX+ CoQ10)Experimental treatment 1 intervention

Group B: Active Comparator (Coenzyme Q10)Active comparator 1 intervention

Trial outcomes

Primary outcomes

Progressive sperm motility

Percentage of sperm showing progressive motility (WHO catagories A+B) on microscopic examination,measured using WHO manual standards,after 30-60 minutes liquefaction, at 37 degree celcius, averaged over two independent readings by trained laboratory technicians blinded to treatment allocatiob

Time frame

Baseline(pre treatment) and 12 weeks after start

Secondary outcomes

Total sperm motility

Percentage of motile sperm (WHO catagories A+B+C) measured on fresh semen samples using WHO semen analysis method (latest edition) .Total motility is the percentage of sperm showing any motility (progressive and non progressive ) at the time of analysis.

Time frame

Baseline (pre treatment) and 12 weeks after start of treatment

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mst.Sumyara Khatun

Lead sponsor

Bangladesh Medical University

Sponsor institution

Bangladesh Medical University

Collaborator

Source ClinicalTrials.gov

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