Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorBrigham Young University
About this trial
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested:
Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry.
Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow.
Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals.
Stable levels of physical activity for at least 6 months
No history of lower extremity injury that would preclude their ability to perform knee extension exercise
Disqualifiers
Cigarette or marijuana smoker
Pregnant or planning to become pregnant within next month
Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment)
Taking prescribed medications (e.g. blood pressure medication) or anti-depressants
Trial design
Design model
Parallel
Treatments tested in this trial
percussive massage
Device30 minutes of percussive massage will be administered twice per day during the 10 day immobilization period using a percussive massage device
Leg Immobilization
Combination productAll subjects will have their left leg immobilized using an immobilization brace for 10 days
Treatment groups
36 Participants
are divided into 2 treatment groupsGroup A: MassageExperimental treatment 2 interventions
Group B: ControlSham comparator 1 intervention
Trial outcomes
Primary outcomes
1
knee extensor muscle strength
Assessed by dynamometry
Time frame
Immediately before the onset of leg immobilization and after 10 days of leg immobilization2
Vastus lateralis cross-sectional area
Assessed by MRI
Time frame
Immediately before the onset of leg immobilization and after 10 days of leg immobilization3
Skeletal muscle mitochondrial function
Assessed in muscle biopsies using in vivo respirometry
Time frame
Immediately before the onset of leg immobilization and after 10 days of leg immobilizationSponsors and contacts
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Source ClinicalTrials.gov