Effect of Periodontal Therapy on Asprosin in Stable Angina
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorOndokuz Mayıs University
About this trial
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis. Asprosin is a novel metabolic biomarker reported to have potential protective roles in cardiovascular diseases and inflammatory processes. The study also investigates the relationship between periodontal parameters and serum asprosin levels before and after periodontal therapy.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Willingness to participate in the study and provide written informed consent
Age 18 years or older
No periodontal treatment within the past 6 months
No use of local or systemic antibiotics within the past 3 months
Disqualifiers
Unwillingness to participate in the study or to provide informed consent
Age under 18 years
Use of local or systemic antibiotics for the treatment of widespread infection within the past 3 months
Receipt of periodontal treatment within the past 6 months
Trial design
Design model
Parallel
Treatments tested in this trial
Non-surgical periodontal therapy (scaling and root planing)
Procedure/SurgeryNon-surgical periodontal therapy will include full-mouth scaling and root planing performed using hand instruments and/or ultrasonic devices to remove supra- and subgingival plaque and calculus.
Non-surgical periodontal therapy (Professional dental cleaning)
Procedure/SurgerySupragingival calculus and plaque removal with standardized oral hygiene instruction.
Treatment groups
60 Participants
are divided into 3 treatment groupsGroup A: Stable angina and periodontitis group (SAP group)Experimental treatment 1 intervention
Group B: Periodontitis group (P group)Experimental treatment 1 intervention
Group C: Control group (C group)Active comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in serum asprosin levels after non-surgical periodontal therapy
Serum asprosin concentrations (ng/mL) will be measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit at baseline and 3 months following non-surgical periodontal therapy.
Time frame
Baseline and 3 monthsSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: