Effect of Physical Activity Pattern on Cardiometabolic Health
ConditionLife Style
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorBrigham and Women's Hospital
About this trial
The goal of this study is to understand the interaction between the circadian system and physical activity.
Participants will:
* complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18-45 yr old
Body mass index (BMI) 18.5 - 34.9 kg/m2
No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
Willing to adhere to the protocol requirements for the duration of the study
Disqualifiers
Currently smoking/vaping or 5 or more years of smoking/vaping
Currently pregnant or breastfeeding
History of drug or alcohol dependency
History of psychiatric illness or disorder
Trial design
Design model
Crossover
Treatments tested in this trial
Exercise intervention
BehavioralResearch participants will be assigned to two exercise conditions.
Treatment groups
26 Participants
are divided into 2 treatment groupsGroup A: Exercise A-B InterventionExperimental treatment 1 intervention
Group B: Exercise B-A InterventionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
glucose level
mean glucose level after exercise session
Time frame
24-hour test period after exercise2
mean arterial pressure
mean arterial pressure after exercise session
Time frame
24-hour test period after exerciseSecondary outcomes
1
insulin sensitivity index
Oral Minimal Model method estimates mean insulin sensitivity based on blood glucose and insulin levels from two mixed meal tests after exercise session
Time frame
about 12 and 24 hours after exercise2
beta-cell function index
Oral Minimal Model method estimates mean beta-cell function based on blood glucose, insulin and c-peptide levels from two mixed meal tests after exercise session
Time frame
about 12 and 24 hours after exercise3
total peripheral resistance
total peripheral resistance derived from BP waveform measured by finger plethysmography
Time frame
24-hour test period after exercise4
autonomic nervous system activity
derived by time-domain heart rate variability analysis
Time frame
24-hour test period after exerciseOther outcomes
1
resting energy expenditure
energy expenditure will be measured at 1-2 hours interval by indirect calorimetry
Time frame
24-hour test period after exercise2
respiratory exchange ratio
respiratory exchange ratio will be measured at 1-2 hours interval by indirect calorimetry
Time frame
24-hour test period after exerciseSponsors and contacts
Click on the lead sponsor to view all of their trials.
Brigham and Women's Hospital
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov