Health TrialsbyHealthPanel

Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis

ConditionsHypokalemic Periodic ParalysisHyperkalemic Periodic Paralysis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRigshospitalet, Denmark

About this trial

This study wishes to investigate the effects of strength exercise in patients with either HypoPP or HyperPP.

The investigators wishes to include participants already diagnosed with either HypoPP or HyperPP in af 24 week prospective study where the patients will be tested and asked to fill out questionnaires three times. These appointments will be schedueled at week 0, week 12 and week 24.

In the time period between week 12 and week 24, the patients will have a personalized strength exercise program, which they will have to follow these 3 months. The exercise will be supervised by one or more of the investigators.

We will also assess the muscle structure and function cross sectionally.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with genetic verified HypoPP or HyperPP

Age minimum 18 years

Able to walk a minimum of 10 meters independently with or without assistive devices and be able to stand from a chair without using hands

Disqualifiers

Other significant cause of muscle weakness

Heart or lung disease which, in the investigator's opinion, makes participation in the study training inadvisable

Anticoagulant treatment

Impaired blood clotting due to disease

Trial design

Design model

Single group

Treatments tested in this trial

  • Strength exercise

    Other intervention

    3 weekly supervised trainings with specific strengt exercises

Treatment groups

36 Participants
are divided into 1 treatment group
Group A: Hypo-/HyperPPExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Functional endurance test in the form of the Five Times Sit-to-Stand Test (5STS)

Time frame
From intervention to end of intervention at 12 weeks

Secondary outcomes

1

Functional endurance test in the form of the 6-Minute Walk Test (6MWT)

Time frame
12 weeks
2

Muscle strength measured with a dynamometer

Dynamometer used: Biodex

Time frame
12 weeks
3

Number of attacks of muscle weakness

Self-reported by participants

Time frame
12 weeks
4

Myotonia graded using the Myotonia Behaviour Scale (MBS)

Scale goes from 0-5, where 0 is no stiffness and 5 is incapacitating stiffness, which demands constant movement to not be totally locked up

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Rigshospitalet, Denmark

Lead sponsor

Source ClinicalTrials.gov
Apply now