This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions.
Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.
Adult patient ≥ 18 years of age
Admitted to intensive care
Requires prophylactic platelet transfusion for thrombocytopenia
Enrolled in a social security program
Recent platelet or red blood cell transfusion (< 24 hours)
Need for urgent red blood cell transfusion due to active bleeding
Patient under guardianship or conservatorship
Significant peripheral edema
Any adult admitted to intensive care, regardless of the reason, who has thrombocytopenia and requires prophylactic platelet transfusion
Cohort
Prospective
Not listed
Assessing the effects of platelet transfusion on endothelial function in the microcirculation. Endothelial function will be measured using a Doppler laser coupled with an acetylcholine iontophoresis system applied to the skin.
The area under the microcirculatory blood flow curve is measured over 10 minutes using a cutaneous laser Doppler sensor coupled with iontophoresis (Périmed, France). The data is analysed using computer software connected to the Doppler device.
Endothelial biomarker levels
Endothelial response will be assessed by measuring circulating levels of syndecan-1, hyaluronic acid, ICAM-1, VCAM-1, E-selectin, endothelial protein C receptor (EPCR), and von Willebrand factor.
Systemic inflammatory biomarker levels
Systemic inflammation will be assessed by measuring C-reactive protein (CRP), leukocyte count, interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), IL-10, CCL2, CCL5, CXCL1, and circulating microparticles.
Oxidative stress
Oxidative stress will be assessed by mass spectrometry.
Peripheral tissue perfusion
Peripheral tissue perfusion will be assessed by measuring skin recolouration time
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